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INSULIN-LIKE GROWTH FACTOR I
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DeCS
Descriptor
English
:
Insulin-Like Growth Factor I
Descriptor
Spanish
:
Factor I del Crecimiento Similar a la Insulina
Descriptor
Portuguese
:
Fator de Crescimento Insulin-Like I
Synonyms
English
:
IGF-I
Somatomedin C
Tree Number:
D12.644.276.937.400
D12.776.124.862.400
D12.776.467.937.400
D23.529.937.400
Definition
English
:
A well-characterized basic peptide believed to be secreted by the
liver
and to circulate in the
blood
. It has growth-regulating, insulin-like, and mitogenic activities. This
growth
factor has a major, but not absolute, dependence on
GROWTH HORMONE
. It is believed to be mainly active in adults in contrast to
INSULIN-LIKE GROWTH FACTOR II
, which is a major fetal
growth
factor.
See Related
English
:
Receptor, IGF Type 1
History Note
English
:
91(86); was see under SOMATOMEDINS 1986-90
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AA
analogs & derivatives
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
22312
Unique Identifier:
D007334
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS